The Study of the Recurrent Sequence of CAG in Three Generations of an Iranian Family Suffering from Huntington Disease via PCR-Sequencing
Ehsan Khodajou1, Ali Nazemi2
1Ehsan Khodajou, Master of Science Genetics, Islamic Azad University, Science and Research (East Azarbaijan). Iran.
2Ali Nazemi, Assistant Professor, Islamic Azad University Branch, Iran.
Manuscript received on January 04, 2017. | Revised Manuscript received on January 11, 2017. | Manuscript published on January 15, 2017. | PP: 22-24 | Volume-2 Issue-8, January 2017. | Retrieval Number: H0138012817
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Abstract: Huntington’s disease (HD) is the most common neurodegenerative one having the dominant autosomal inheritance which is being characterized by the excessive uncontrolled motor movements and the deficits in the emotional and cognitive functions. The mutation responsible for Huntington disease leads polyglutamine protein to be distributed in Huntington protein which carries more toxic functions towards Huntington protein. The aim of the study is to design a PCR system to diagnose Huntington disease which can detect the genotype of the disease.
Keywords: Huntington, PCR, CAG sequence.